A Guide to Sample Size for Animal based Studies

A Guide to Sample Size for Animal-based Studies

Author/Editor: Penny S. Reynolds

Overview

A Guide to Sample Size for Animal-based Studies is a rigorous, practical handbook designed to help researchers calculate optimal group sizes for ethical and statistically sound animal experiments. Authored by biostatistician and researcher Penny S. Reynolds, this text bridges the gap between statistical theory and practical experimental design. It serves as an essential manual for biomedical researchers, veterinarians, and graduate students striving to improve research validity and animal welfare compliance.

Key Topics Covered
Statistical Power & Significance: Fundamental concepts governing error rates, effect sizes, and power calculations in preclinical studies.
Experimental Design Principles: Methodologies for reducing animal numbers while maximizing data quality through rigorous design frameworks.
Sample Size Calculation Methods: Step-by-step guidance on applying statistical formulas and software tools for diverse animal models.
Ethical & Regulatory Compliance: Alignment with the Three Rs (Replacement, Reduction, Refinement) and institutional animal care and use committee standards.